Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
نویسندگان
چکیده
منابع مشابه
The Link between Protein Kinase CK2 and Atypical Kinase Rio1
The atypical kinase Rio1 is widespread in many organisms, ranging from Archaebacteria to humans, and is an essential factor in ribosome biogenesis. Little is known about the protein substrates of the enzyme and small-molecule inhibitors of the kinase. Protein kinase CK2 was the first interaction partner of Rio1, identified in yeast cells. The enzyme from various sources undergoes CK2-mediated p...
متن کاملStructure and activity of the atypical serine kinase Rio1.
Rio1 is the founding member of the RIO family of atypical serine kinases that are universally present in all organisms from archaea to mammals. Activity of Rio1 was shown to be absolutely essential in Saccharomyces cerevisiae for the processing of 18S ribosomal RNA, as well as for proper cell cycle progression and chromosome maintenance. We determined high-resolution crystal structures of Archa...
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An understanding of how genes move between and within populations of parasitic nematodes is important in combating the evolution and spread of anthelmintic resistance. Much has been learned by studying mitochondrial DNA markers, but autosomal markers such as microsatellites have been applied to only a few nematode species, despite their many advantages for studying gene flow in eukaryotes. Here...
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To the Editor: In April 2009, a 47-year-old woman in Saint-Jeannet in southern France reported stomach aches, abdominal bloating, and occasional diarrhea. Blood analyses found an increased eosinophil level (8,800 cells/mm 3), which represented 52% of 16,900 leukocytes/mm 3. Parasitologic examinations for helminths were conducted with 6 fecal specimens obtained during June 9– July 2, 2009. Analy...
متن کاملThe atypical protein kinase Cs
Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play critical roles in signaling pathways that control cell growth, differentiation and survival. Recently, several investigators have identified a number of aPKC-interacting proteins whose characterization is helping to un...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2008
ISSN: 1756-3305
DOI: 10.1186/1756-3305-1-34